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Article

Male sex determination: insights into molecular mechanisms

19 Dec 2011

Abstract excerpt

Disorders of sex development often arise from anomalies in the molecular or cellular networks that guide the differentiation of the embryonic gonad into either a testis or an ovary, two functionally distinct organs. The activation of the Y-linked gene Sry (sex-determining region Y) and its downstream target Sox9 (Sry box-containing gene 9) triggers testis differentiation by stimulating the differentiation of...

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PMID: 22179516
DOI: 10.1038/aja.2011.169

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