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Article

Homozygous inactivation of Sox9 causes complete XY sex reversal in mice.

Biology of reproduction - 1 Jan 2006

Barrionuevo Francisco, Bagheri-Fam Stefan, Klattig Jürgen, Kist Ralf, Taketo Makoto M, Englert Christoph, Scherer Gerd

Abstract excerpt

In the presence of the Y-chromosomal gene Sry, the bipotential mouse gonads develop as testes rather than as ovaries. The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry. Sox9 is thus sufficient but not necessarily essential for testis induction. Mutational inactivation of one allele of SOX9/Sox9 causes sex reversal in humans but not in mice....

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Source

Identifiers

PMID: 16207837
DOI: 10.1095/biolreprod.105.045930

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygous inactivation of Sox9 causes complete XY sex reversal in mice.PMID 16207837Read ↗

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex ReversalsSemantic proximity Read ↗

Sox9 induces testis development in XX transgenic mice.Semantic proximity Read ↗

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse.Semantic proximity Read ↗

Turning on the male--SRY, SOX9 and sex determination in mammals.Semantic proximity Read ↗

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.Semantic proximity Read ↗

Functional analysis of <i>Sox8</i> and <i>Sox9</i> during sex determination in the mouseSemantic proximity Read ↗

<i>Sox9</i> in Testis DeterminationSemantic proximity Read ↗

Sex with two SOX on: SRY and SOX9 in testis development.Semantic proximity Read ↗

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversalsSemantic proximity Read ↗

XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytesSemantic proximity Read ↗

Heterozygous deletion of Sox9 in mouse mimics the gonadal sex reversal phenotype associated with campomelic dysplasia in humans.Semantic proximity Read ↗

<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

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