Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.

The Journal of clinical endocrinology and metabolism - 1 Aug 2007

Sutherland Alison, Davies Jocelyn, Owen Catherine J, Vaikkakara Suresh, Walker Christine, Cheetham Timothy D, James R Andrew, Perros Petros, Donaldson Peter T, Cordell Heather J, Quinton Richard, Pearce Simon H S

Abstract excerpt

CONTEXT: A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes. Previous investigations have also demonstrated that an intronic polymorphism (termed PD1.3; SNP ID rs11568821) in the programmed cell death (PDCD1) gene...

Read the complete abstract on PubMed

Topics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cohort Studies
Share to DEAD-box RNA Helicases
Share to Graves Disease
Share to Interferon-Induced Helicase, IFIH1
Share to Odds Ratio
Share to Polymorphism, Genetic
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 17535987
DOI: 10.1210/jc.2007-0173
PMCID: PMC6952273

Genes

IFIH1
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.PMID 17535987Read ↗

Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.Semantic proximity Read ↗

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Semantic proximity Read ↗

An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.Semantic proximity Read ↗

Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach.Semantic proximity Read ↗

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.Semantic proximity Read ↗

The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.Semantic proximity Read ↗

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.Semantic proximity Read ↗

Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the IFIH1 gene with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Interferon induced with helicase C domain 1 (IFIH1): trends on helicase domain and type 1 diabetes onset.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.