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Article

Carriers of rare missense variants in IFIH1 are protected from psoriasis.

The Journal of investigative dermatology - 1 Dec 2010

Li Yonghong, Liao Wilson, Cargill Michele, Chang Monica, Matsunami Nori, Feng Bing-Jian, Poon Annie, Callis-Duffin Kristina P, Catanese Joseph J, Bowcock Anne M, Leppert Mark F, Kwok Pui-Yan, Krueger Gerald G, Begovich Ann B

Abstract excerpt

Testing of ∼25,000 putative functional single-nucleotide polymorphisms (SNPs) across the human genome in a genetic association study has identified three psoriasis genes, IL12B, IL23R, and IL13. We now report evidence for the association of psoriasis risk with missense SNPs in the interferon induced with helicase C domain 1 gene (IFIH1). The rare alleles of two independent SNPs were associated with decreased risk...

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Share to Autoimmunity
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Interferon-Induced Helicase, IFIH1

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Psoriasis

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20668468
DOI: 10.1038/jid.2010.214
PMCID: PMC3680368

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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