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Article

Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases.

Autoimmunity reviews - 1 Apr 2006

Steiman-Shimony Avital, Edelman Hanna, Barak Michal, Shahaf Gitit, Dunn-Walters Deborah, Stott David I, Abraham Roshini S, Mehr Ramit

Abstract excerpt

Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for analyzing the graphical properties of IgV gene lineage trees, allowing quantification of the differences between the dynamics of SHM and antigen-driven selection...

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Source

Identifiers

PMID: 16697964
DOI: 10.1016/j.autrev.2005.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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