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AncesTree: An interactive immunoglobulin lineage tree visualizer

10 Jul 2020

Abstract excerpt

High-throughput sequencing of human immunoglobulin genes allows analysis of antibody repertoires and the reconstruction of clonal lineage evolution. The study of antibodies (Abs) affinity maturation is of specific interest to understand the generation of Abs with high affinity or broadly neutralizing activities. Moreover, phylogenic analysis enables the identification of the key somatic mutations required to...

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PMID: 32649725
DOI: 10.1371/journal.pcbi.1007731

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