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Article

Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection.

Cellular immunology - 1 Dec 2006

Steiman-Shimony Avital, Edelman Hanna, Hutzler Anat, Barak Michal, Zuckerman Neta S, Shahaf Gitit, Dunn-Walters Deborah, Stott David I, Abraham Roshini S, Mehr Ramit

Abstract excerpt

Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues. Lineage trees depict the diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. We previously developed an algorithm for quantifying the graphical properties...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17434468
DOI: 10.1016/j.cellimm.2007.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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