Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Joining-chain (J-chain) negative mice are B cell memory deficient.

European journal of immunology - 1 Jun 2006

Källberg Eva, Leanderson Tomas

Abstract excerpt

The systemic immune response of joining-chain (J-chain)-deficient mice (J(-/-) mice) on a C57BL/6 background against the hapten 4-hydroxy-3-nitrophenyl (NP) was analysed. While primary IgG responses to the hapten were similar to those observed in WT control animals, secondary immune responses were compromised both at the level of serum IgG and the number of responding B cells. The repertoire switch from lambda to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to B-Lymphocytes
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haptens

Share to Immunity, Cellular

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin J-Chains

Share to Immunologic Memory

Source

Identifiers

PMID: 16688681
DOI: 10.1002/eji.200635981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Joining-chain (J-chain) negative mice are B cell memory deficient.PMID 16688681Read ↗

Canonical germinal center B cells may not dominate the memory response to antigenic challenge.Semantic proximity Read ↗

Ig VH hypermutation is absent in the germinal centers of aged mice.Semantic proximity Read ↗

Development and maintenance of a B220- memory B cell compartment.Semantic proximity Read ↗

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.Semantic proximity Read ↗

The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.Semantic proximity Read ↗

Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response.Semantic proximity Read ↗

Age‐related changes in antibody repertoire: contribution from T cellsSemantic proximity Read ↗

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.Semantic proximity Read ↗

Regulation of VH gene repertoire and somatic mutation in germinal centre B cells by passively administered antibody.Semantic proximity Read ↗

Antigen-driven B cell differentiation in vivo.Semantic proximity Read ↗

Somatic hypermutation in mouse lambda chains.Semantic proximity Read ↗

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.