Article

Effects of ADAM10 deletion on APP shedding, synapse and synaptic plasticity in adult mice

2025-12-16

Abstract excerpt

<title>Abstract</title> <p> A disintegrin and metalloproteinase 10 (ADAM10) is a member of the ADAMs (a deintegrin and metalloproteinases) family, which hydrolyzes various cellular receptors and signaling molecules (such as APP) to regulate the development of body organs and tissues. As ADAM10 is a susceptibility gene for Alzheimer's disease (AD), we generated adult neural cell-specific <italic>ADAM10</italic>...

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Literature Corpus work: 6987d4c9-6cc7-52f3-8c77-61c52f820754
DOI: 10.21203/rs.3.rs-8193475/v1

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