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Article

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population.

British journal of cancer - 19 Jun 2006

Lesueur F, Song H, Ahmed S, Luccarini C, Jordan C, Luben R, Easton D F, Dunning A M, Pharoah P D, Ponder B A J

Abstract excerpt

A substantial proportion of the familial risk of breast cancer may be attributable to genetic variants each contributing a small effect. pRb controls the cell cycle and polymorphisms within it are candidates for such low penetrance susceptibility alleles, since the gene has been implicated in several human tumours, particularly breast cancer. The purpose of this study was to determine whether common variants in...

Topics

Aged
Breast Neoplasms
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Middle Aged
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Retinoblastoma Protein

Risk Factors

United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 16685266
DOI: 10.1038/sj.bjc.6603160
PMCID: PMC2361346

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