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Article

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population.

British journal of cancer - 19 Jun 2006

Lesueur F, Song H, Ahmed S, Luccarini C, Jordan C, Luben R, Easton D F, Dunning A M, Pharoah P D, Ponder B A J

Abstract excerpt

A substantial proportion of the familial risk of breast cancer may be attributable to genetic variants each contributing a small effect. pRb controls the cell cycle and polymorphisms within it are candidates for such low penetrance susceptibility alleles, since the gene has been implicated in several human tumours, particularly breast cancer. The purpose of this study was to determine whether common variants in...

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Identifiers

PMID: 16685266
DOI: 10.1038/sj.bjc.6603160
PMCID: PMC2361346

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