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Article

Conservation of the RB1 gene in human and primates.

Human mutation - 1 Apr 2005

Sivakumaran Theru A, Shen Peidong, Wall Dennis P, Do Bao H, Kucheria Kiran, Oefner Peter J

Abstract excerpt

Mutations in the RB1 gene are associated with retinoblastoma, which has served as an important model for understanding hereditary predisposition to cancer. Despite the great scrutiny that RB1 has enjoyed as the prototypical tumor suppressor gene, it has never been the object of a comprehensive survey of sequence variation in diverse human populations and primates. Therefore, we analyzed the coding (2,787 bp) and...

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PMID: 15776430
DOI: 10.1002/humu.20154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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