Article
Common variants in RB1 gene and risk of invasive ovarian cancer.
Cancer research - 15 Oct 2006
Song Honglin, Ramus Susan J, Shadforth Danielle, Quaye Lydia, Kjaer Susanne Kruger, Dicioccio Richard A, Dunning Alison M, Hogdall Estrid, Hogdall Claus, Whittemore Alice S, McGuire Valerie, Lesueur Fabienne, Easton Douglas F, Jacobs Ian J, Ponder Bruce A J, Gayther Simon A, Pharoah Paul D P
Abstract excerpt
Somatic alteration of the RB1 gene is common in several types of cancer, and germ-line variants are implicated in others. We have used a single nucleotide polymorphism (SNP) tagging approach to evaluate the association between common variants (SNP) in RB1 and risks of invasive ovarian cancer. We genotyped 11 tagging SNPs in three ovarian case-control studies from the United Kingdom, United States, and Denmark,...
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