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Article

Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population.

Human molecular genetics - 1 Feb 1997

Dunning A M, Chiano M, Smith N R, Dearden J, Gore M, Oakes S, Wilson C, Stratton M, Peto J, Easton D, Clayton D, Ponder B A

Abstract excerpt

Most multiple case families of young onset breast cancer and ovarian cancer are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. However, these mutations are uncommon in the population and they probably account for only a few percent of all breast cancer...

Topics

Adult
Aged
Alleles
BRCA1 Protein
Breast Neoplasms
Case-Control Studies
Cohort Studies
Female
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Ovarian Neoplasms

Source

Identifiers

PMID: 9063749
DOI: 10.1093/hmg/6.2.285

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9063749-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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