Article
Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.
Human molecular genetics - 1 Dec 2011
Cox David G, Simard Jacques, Sinnett Daniel, Hamdi Yosr, Soucy Penny, Ouimet Manon, Barjhoux Laure, Verny-Pierre Carole, McGuffog Lesley, Healey Sue, Szabo Csilla, Greene Mark H, Mai Phuong L, Andrulis Irene L, Thomassen Mads, Gerdes Anne-Marie, Caligo Maria A, Friedman Eitan, Laitman Yael, Kaufman Bella, Paluch Shani S, Borg Åke, Karlsson Per, Askmalm Marie Stenmark, Bustinza Gisela Barbany, Nathanson Katherine L, Domchek Susan M, Rebbeck Timothy R, Benítez Javier, Hamann Ute, Rookus Matti A, van den Ouweland Ans M W, Ausems Margreet G E M, Aalfs Cora M, van Asperen Christi J, Devilee Peter, Gille Hans J J P, Peock Susan, Frost Debra, Evans D Gareth, Eeles Ros, Izatt Louise, Adlard Julian, Paterson Joan, Eason Jacqueline, Godwin Andrew K, Remon Marie-Alice, Moncoutier Virginie, Gauthier-Villars Marion, Lasset Christine, Giraud Sophie, Hardouin Agnès, Berthet Pascaline, Sobol Hagay, Eisinger François, Bressac de Paillerets Brigitte, Caron Olivier, Delnatte Capucine, Goldgar David, Miron Alex, Ozcelik Hilmi, Buys Saundra, Southey Melissa C, Terry Mary Beth, Singer Christian F, Dressler Anne-Catharina, Tea Muy-Kheng, Hansen Thomas V O, Johannsson Oskar, Piedmonte Marion, Rodriguez Gustavo C, Basil Jack B, Blank Stephanie, Toland Amanda E, Montagna Marco, Isaacs Claudine, Blanco Ignacio, Gayther Simon A, Moysich Kirsten B, Schmutzler Rita K, Wappenschmidt Barbara, Engel Christoph, Meindl Alfons, Ditsch Nina, Arnold Norbert, Niederacher Dieter, Sutter Christian, Gadzicki Dorothea, Fiebig Britta, Caldes Trinidad, Laframboise Rachel, Nevanlinna Heli, Chen Xiaoqing, Beesley Jonathan, Spurdle Amanda B, Neuhausen Susan L, Ding Yuan C, Couch Fergus J, Wang Xianshu, Peterlongo Paolo, Manoukian Siranoush, Bernard Loris, Radice Paolo, Easton Douglas F, Chenevix-Trench Georgia, Antoniou Antonis C, Stoppa-Lyonnet Dominique, Mazoyer Sylvie, Sinilnikova Olga M
Abstract excerpt
Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mechanism that is particularly instrumental in safeguarding cells against tumorigenesis. We hypothesized that polymorphisms that alter the expression...
