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Article

Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.

PloS one - 7 Mar 2007

Song Honglin, Ramus Susan J, Kjaer Susanne Krüger, Hogdall Estrid, Dicioccio Richard A, Whittemore Alice S, McGuire Valerie, Hogdall Claus, Jacobs Ian J, Easton Douglas F, Ponder Bruce A J, Dunning Alison M, Gayther Simon A, Pharoah Paul D P

Abstract excerpt

BACKGROUND: BRIP1 interacts with BRCA1 and functions in regulating DNA double strand break repair pathways. Germline BRIP1 mutations are associated with breast cancer and Fanconi anemia. Thus, common variants in the BRIP1 are candidates for breast and ovarian cancer susceptibility. METHODS: We used a SNP tagging approach to evaluate the association between common variants (minor allele frequency>or=0.05) in BRIP1...

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Source

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Identifiers

PMID: 17342202
DOI: 10.1371/journal.pone.0000268
PMCID: PMC1800910

Genes

BRIP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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