Article
A common variant associated with prostate cancer in European and African populations.
Nature genetics - 1 Jun 2006
Amundadottir Laufey T, Sulem Patrick, Gudmundsson Julius, Helgason Agnar, Baker Adam, Agnarsson Bjarni A, Sigurdsson Asgeir, Benediktsdottir Kristrun R, Cazier Jean-Baptiste, Sainz Jesus, Jakobsdottir Margret, Kostic Jelena, Magnusdottir Droplaug N, Ghosh Shyamali, Agnarsson Kari, Birgisdottir Birgitta, Le Roux Louise, Olafsdottir Adalheidur, Blondal Thorarinn, Andresdottir Margret, Gretarsdottir Olafia Svandis, Bergthorsson Jon T, Gudbjartsson Daniel, Gylfason Arnaldur, Thorleifsson Gudmar, Manolescu Andrei, Kristjansson Kristleifur, Geirsson Gudmundur, Isaksson Helgi, Douglas Julie, Johansson Jan-Erik, Bälter Katarina, Wiklund Fredrik, Montie James E, Yu Xiaoying, Suarez Brian K, Ober Carole, Cooney Kathleen A, Gronberg Henrik, Catalona William J, Einarsson Gudmundur V, Barkardottir Rosa B, Gulcher Jeffrey R, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The...
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