Article
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers.
Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006
Drakenberg Katarina, Nikoshkov Andrej, Horváth Monika Cs, Fagergren Pernilla, Gharibyan Anna, Saarelainen Kati, Rahman Sadia, Nylander Ingrid, Bakalkin Georgy, Rajs Jovan, Keller Eva, Hurd Yasmin L
Abstract excerpt
Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu opioid receptor gene (OPRM1) has been linked with heroin abuse. In our population of European Caucasians (n = 118), approximately 90% of 118G allelic carriers were heroin users. Postmortem brain analyses showed the OPRM1 genotype associated with transcription, translation, and processing of the human striatal opioid neuropeptide...
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