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Article

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin.

Human mutation - 1 Apr 2002

Shi Jinxiu, Hui Lijian, Xu Yonghai, Wang Feng, Huang Wei, Hu Gengxi

Abstract excerpt

Human mu-opioid receptor (OPRM1) is the major site for the analgesic action of most opioid drugs such as morphine, methadone and heroin. It was previously reported that a single nucleotide polymorphism (SNP) in exon1 (c.118A-->G) of OPRM1 might modestly alter the affinity in beta-endorphin-Mu interaction. Using denaturing high performance liquid chromatography (DHPLC) the complete coding region of the OPRM1 gene...

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Source

Identifiers

PMID: 11933204
DOI: 10.1002/humu.9026

Genes

OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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