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Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin

26 Oct 2010

Abstract excerpt

BACKGROUND: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-promoting cell signalling in normal epithelial cells is less well understood and frequently contradictory. The potential for E-cadherin to co-ordinate different...

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PMID: 21049033
DOI: 10.1371/journal.pone.0013621

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