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Article

Cell culture dimensionality influences mesenchymal stem cell fate through cadherin-2 and cadherin-11

21 May 2020

Abstract excerpt

The acquisition of a specific cell fate is one of the core aims of tissue engineering and regenerative medicine. Significant evidence shows that aggregate cultures have a positive influence on cell fate decisions, presumably through cell-cell interactions, but little is known about the specific mechanisms. To investigate the difference between cells cultured as a monolayer and as aggregates, we started by looking...

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PMID: 32480096
DOI: 10.1016/j.biomaterials.2020.120127

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