Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs.

Channels (Austin, Tex.) - 1 Jan 2016

Motin Leonid, Durek Thomas, Adams David J

Abstract excerpt

Nine different voltage-gated sodium channel isoforms are responsible for inducing and propagating action potentials in the mammalian nervous system. The Nav1.7 channel isoform plays an important role in conducting nociceptive signals. Specific mutations of this isoform may impair gating behavior of the channel resulting in several pain syndromes. In addition to channel mutations, similar or opposite changes in...

Topics

Animals
CHO Cells
Cricetulus
Gene Expression
Humans
Ion Channel Gating
Kinetics
Membrane Potentials
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Recombinant Proteins

Scorpion Venoms

Scorpions

Sodium

Source

Open in PubMed Open full text

Identifiers

PMID: 26646206
DOI: 10.1080/19336950.2015.1120392
PMCID: PMC4960991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26646206-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs.PMID 26646206Read ↗

A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain.Semantic proximity Read ↗

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.Semantic proximity Read ↗

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Nav1.7.Semantic proximity Read ↗

Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels.Semantic proximity Read ↗

Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels.Semantic proximity Read ↗

Nav1.7 gating in human iPSC derived sensory neurons: an experimental and computational studySemantic proximity Read ↗

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.Semantic proximity Read ↗

Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Semantic proximity Read ↗

Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.Semantic proximity Read ↗

µ-Conotoxins Modulating Sodium Currents in Pain Perception and TransmissionSemantic proximity Read ↗

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.Semantic proximity Read ↗

Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.