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Ras-Related Mutants Identified in Young-Onset Colorectal Cancer Display Divergent Phenotypes and Retain Their Pro-Angiogenic Effects.

Cells - 14 Feb 2026

David Andrei Phillip L, Galvez Mariko Isabelle P, Chua Sidney Allen A, Leaño Dominique Mickai G, Sacdalan Dennis L, Garcia Reynaldo L

Abstract excerpt

The Ras-related (RRAS) gene is a member of the Ras superfamily and remains largely uncharacterized compared to KRAS, NRAS, and HRAS. Its role in tumorigenesis remains poorly documented, as evidenced by its lack of canonical mutations in any cancer type. This study investigated the effects of the novel RRAS R78W and E63D mutants-identified in Filipino young-onset colorectal cancer (YO-CRC) patients-on cancer...

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Identifiers

PMID: 41744792
DOI: 10.3390/cells15040349
PMCID: PMC12939121

Genes

RRAS
HRAS
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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