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Article

Across the universe of K-RAS mutations in non-small-cell-lung cancer.

Current pharmaceutical design - 1 Jan 2014

Piva Sheila, Ganzinelli Monica, Garassino Marina Chiara, Caiola Elisa, Farina Gabriella, Broggini Massimo, Marabese Mirko

Abstract excerpt

RAS family proteins are important signaling molecules that regulate cell growth, survival and differentiation by coupling receptor activation to downstream effector pathways. Three distinct genes encode for the three different proteins H-, K-, and N- RAS. These proteins share high sequence homology, particularly at the N-Terminal domain. Among them, K-RAS is one of the most frequently mutated in human cancer. The...

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Source

Identifiers

PMID: 24138715
DOI: 10.2174/13816128113196660761

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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