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Article

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress.

Haematologica - 1 Apr 2015

Jayapal Senthil Raja, Wang Chelsia Qiuxia, Bisteau Xavier, Caldez Matias J, Lim Shuhui, Tergaonkar Vinay, Osato Motomi, Kaldis Philipp

Abstract excerpt

Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts are embryonic lethal due to heart defects, and this precludes the investigation of their overlapping roles in definitive hematopoiesis. Here we use a conditional knockout mouse model to investigate the effect of...

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Identifiers

PMID: 25616574
DOI: 10.3324/haematol.2014.106468
PMCID: PMC4380715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25616574-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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