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Keeping mammalian mutation load in check: regulation of the activity of error-prone DNA polymerases by p53 and p21.

Cell cycle (Georgetown, Tex.) - 1 Sept 2006

Livneh Zvi

Abstract excerpt

To overcome DNA lesions that block replication the cell employs translesion DNA synthesis (TLS) polymerases, a group of low fidelity DNA polymerases that have the capacity to bypass a wide range of DNA lesions. This TLS process is also termed error-prone repair, due to its inherent mutagenic natu...

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Identifiers

PMID: 16969082
DOI: 10.4161/cc.5.17.3193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16969082-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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