Article
Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.
Developmental biology - 15 Jan 2007
Erickson Timothy, Scholpp Steffen, Brand Michael, Moens Cecilia B, Waskiewicz Andrew Jan
Abstract excerpt
Pbx proteins are a family of TALE-class transcription factors that are well characterized as Hox co-factors acting to impart segmental identity to the hindbrain rhombomeres. However, no role for Pbx in establishing more anterior neural compartments has been demonstrated. Studies done in Drosophila show that Engrailed requires Exd (Pbx orthologue) for its biological activity. Here, we present evidence that...
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