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Article

Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation.

FEBS letters - 2 Apr 2009

Selvamurugan Nagarajan, Shimizu Emi, Lee Minnkyong, Liu Tong, Li Hong, Partridge Nicola C

Abstract excerpt

Matrix metalloproteinase-13 (MMP-13) plays a critical role in parathyroid hormone (PTH)-induced bone resorption. PTH acts via protein kinase A (PKA) to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter activation. We show here that PTH stimulated Runx2 phosphorylation in rat osteoblastic cells. Runx2 was phosphorylated on serine 28 and threonine 340 after 8-bromo cyclic adenosine mono...

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Source

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Identifiers

PMID: 19264160
DOI: 10.1016/j.febslet.2009.02.040
PMCID: PMC4640702

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation.PMID 19264160Read ↗

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