Article
Role of protein kinase A in the regulation of cytosolic free calcium in human osteoblast-like SaOS-2 cells.
The American journal of physiology - 1 Feb 1993
Fukayama S, Tashjian A H, Bringhurst F R
Abstract excerpt
We have used wild-type and adenosine 3',5'-cyclic monophosphate (cAMP)-resistant mutant osteoblast-like SaOS-2 cells to investigate the role of protein kinase A (PKA) in the regulation of cytosolic free Ca2+ concentration ([Ca2+]i). Basal levels of [Ca2+]i were the same in wild-type (127 +/- 6.1...
Topics
- Bucladesine
- Calcium
- Calcium-Transporting ATPases
- Cell Line
- Cyclic AMP
- Cytosol
- Drug Combinations
- Drug Resistance
- Humans
- Ionomycin
- Mutation
- Osmolar Concentration
- Osteoblasts
- Phenotype
- Protein Kinase Inhibitors
- Protein Kinases
- Terpenes
- Thapsigargin