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Article

Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2006

Van De Wiele C Justin, Joachims Michelle L, Fesler Amy M, Vaughn James G, Blackburn Michael R, McGee Stephanie T, Thompson Linda F

Abstract excerpt

Murine fetal thymic organ culture (FTOC) was used to investigate the mechanism by which a lack of adenosine deaminase (ADA) leads to a failure of T cell production in the thymus. We previously showed that T cell development was inhibited beginning at the CD4(-)CD8(-)CD25(+)CD44(low) stage in ADA-deficient FTOC initiated at day 15 of gestation when essentially all thymocytes are CD4(-)CD8(-). In the present study,...

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Identifiers

PMID: 16670300
DOI: 10.4049/jimmunol.176.10.5925
PMCID: PMC1550651

Genes

ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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