Article
Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 1995
Wakamiya M, Blackburn M R, Jurecic R, McArthur M J, Geske R S, Cartwright J, Mitani K, Vaishnav S, Belmont J W, Kellems R E
Abstract excerpt
We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA subs...
Topics
- Adenosine Deaminase
- Adenosine Triphosphate
- Aging
- Animals
- Deoxyadenine Nucleotides
- Female
- Genes, Lethal
- Genotype
- Gestational Age
- Hematopoietic Stem Cells
- Homeostasis
- Leukocytes
- Liver
- Mice