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Article

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice.

The Journal of biological chemistry - 21 Jun 1996

Blackburn M R, Datta S K, Wakamiya M, Vartabedian B S, Kellems R E

Abstract excerpt

Adenosine deaminase (ADA; EC 3.5.4.4) deficiency in humans is an autosomal recessive genetic disorder that results in severe combined immunodeficiency disease. ADA-deficient mice generated by targeted gene disruption die perinatally, preventing postnatal analysis of ADA deficiency. We have recently rescued ADA-deficient fetuses from perinatal lethality by expression of an ADA minigene in the placentas of...

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Source

Identifiers

PMID: 8663040
DOI: 10.1074/jbc.271.25.15203

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Metabolic and immunologic consequences of limited adenosine deaminase expression in mice.PMID 8663040Read ↗

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The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.Semantic proximity Read ↗

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice.Semantic proximity Read ↗

Adenosine deaminase deficiency: a reviewSemantic proximity Read ↗

Adenosine deaminase deficiency in adults.Semantic proximity Read ↗

Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.Semantic proximity Read ↗

ADAR1 is vital for B cell lineage development in the mouse bone marrowSemantic proximity Read ↗

Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta.Semantic proximity Read ↗

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