Article
Metabolic and immunologic consequences of limited adenosine deaminase expression in mice.
The Journal of biological chemistry - 21 Jun 1996
Blackburn M R, Datta S K, Wakamiya M, Vartabedian B S, Kellems R E
Abstract excerpt
Adenosine deaminase (ADA; EC 3.5.4.4) deficiency in humans is an autosomal recessive genetic disorder that results in severe combined immunodeficiency disease. ADA-deficient mice generated by targeted gene disruption die perinatally, preventing postnatal analysis of ADA deficiency. We have recent...
Topics
- Adenosine Deaminase
- Adenosylhomocysteinase
- Aging
- Animals
- B-Lymphocytes
- Cells, Cultured
- Death
- Genotype
- Hydrolases
- Immunologic Deficiency Syndromes
- Lymphocyte Activation
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Nucleosides
- Nucleotides
- Organ Specificity
- Spleen