Human postnatal thymocytes generate phenotypically immature CD3dim, CD5dim, CD1abright progeny in organ culture.

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Article

Human postnatal thymocytes generate phenotypically immature CD3dim, CD5dim, CD1abright progeny in organ culture.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992

Merkenschlager M, Fisher A G

Abstract excerpt

We previously described an organ culture system that supports the in vitro development of human fetal thymocytes in murine alymphoid thymic rudiments without addition of exogenous factors. This approach to study human T cell precursors is limited by the requirement for fetal tissue. We show that...

Topics

Animals
Antigens, CD
Antigens, CD1
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
CD5 Antigens
Child
Hematopoietic Stem Cells
Humans
Infant
Infant, Newborn
Mice
Organ Culture Techniques
Phenotype
Receptors, Antigen, T-Cell
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1371127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1371127-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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