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Article

Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.

Biochemistry - 9 May 2017

Crabtree Michael D, Borcherds Wade, Poosapati Anusha, Shammas Sarah L, Daughdrill Gary W, Clarke Jane

Abstract excerpt

Appropriate integration of cellular signals requires a delicate balance of ligand-target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in these cellular processes, has been shown previously to enhance binding affinities and alter cellular function. Conserved proline residues are commonly found flanking regions of IDPs that...

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Share to Histone-Lysine N-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28425697
DOI: 10.1021/acs.biochem.7b00179
PMCID: PMC5467178

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