Article
Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo
27 Sept 2018
Abstract excerpt
Hematopoietic stem cells constitute a unique subpopulation of blood cells that can give rise to all types of mature cells in response to physiological demands. However, the intrinsic molecular machinery that regulates this transformative property remains elusive. In this paper, we demonstrate that small GTPase Rheb1 is a critical regulator of proliferation and differentiation of hematopoietic stem cells in vivo....
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