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Article

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

15 Oct 2014

Abstract excerpt

Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific functions of these pathways in AML are unclear, thwarting the rational application of targeted therapeutics. To elucidate the downstream functions of activated NRAS in AML, we used a murine model that harbors Mll-AF9 and a tetracycline-repressible,...

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PMID: 25316678
DOI: 10.1182/blood-2013-08-521708

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