Article
Analysis of RET polymorphisms and haplotypes in the context of sporadic medullary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Apr 2006
Fernández Raquel M, Peciña Ana, Antiñolo Guillermo, Navarro Elena, Borrego Salud
Abstract excerpt
CONTEXT: Little is known about the etiology of sporadic medullary thyroid carcinoma (sMTC). While germline gain-of-function mutations in the RET proto-oncogene cause hereditary MTC, the molecular mechanisms leading to the sporadic forms remain obscure. Our group had evidence about the existence of a low-penetrance susceptibility locus for sMTC in linkage disequilibrium with RET variants S836S/IVS1-126G>T, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
