[Genetic polymorphisms: implications in the pathogenesis of medullary thyroid carcinoma].

doi:10.1590/s0004-27302007000500009

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Article

[Genetic polymorphisms: implications in the pathogenesis of medullary thyroid carcinoma].

Arquivos brasileiros de endocrinologia e metabologia - 1 Jul 2007

Rocha Andreia Possatti da, Magalhães Patrícia K Ribeiro, Maia Ana Luiza, Maciel Lea Maria Zanini

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare malignant neoplasia, which may occur on sporadic form or on a hereditary basis. Germ line mutations in the RET proto-oncogene is responsible for hereditary MTC. However, most MTC occur in individuals without family history where the pathogenesis is still unclear. Single nucleotide polymorphisms (SNPs) of the RET gene have been described in the general population as well...

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PMID: 17891235
DOI: 10.1590/s0004-27302007000500009

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Source receipt: pubmed, retrieved 6 Sept 2026.