Article
Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation.
Oncogene - 11 Feb 1999
Gimm O, Neuberg D S, Marsh D J, Dahia P L, Hoang-Vu C, Raue F, Hinze R, Dralle H, Eng C
Abstract excerpt
The aetiology of sporadic medullary thyroid carcinoma is unknown. About 50% harbour a somatic mutation at codon 918 of RET (M918T). To investigate whether other RET sequence variants may be associated with or predispose to the development of sporadic medullary thyroid carcinoma, we analysed genomic DNA from the germline and corresponding tumour from 50 patients to identify RET sequence variants. In one patient,...
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