Article
Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2015
Lee Jongwon, Youn Bang Ung, Kim Kabsun, Kim Jung Ha, Lee Da-Hye, Seong Semun, Kim Inyoung, Han Seung-Hee, Che Xiangguo, Choi Je-Yong, Park Yong-Wook, Kook Hyun, Kim Kyung Keun, Lim Dae-Sik, Kim Nacksung
Abstract excerpt
Mammalian sterile 20-like kinase 2 (Mst2) plays a central role in the Hippo pathway, controlling cell proliferation, differentiation, and apoptosis during development. However, the roles of Mst2 in osteoclast and osteoblast development are largely unknown. Here, we demonstrate that mice deficient in Mst2 exhibit osteoporotic phenotypes with increased numbers of osteoclasts and decreased numbers of osteoblasts as...
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