Article
Rapid detection of the fluoroquinolone resistance-associated ParC mutation in Neisseria gonorrhoeae using TaqMan probes.
International journal of urology : official journal of the Japanese Urological Association - 1 Mar 2006
Shigemura Katsumi, Shirakawa Toshiro, Tanaka Kazushi, Arakawa Soichi, Gotoh Akinobu, Fujisawa Masato
Abstract excerpt
BACKGROUND: In fluoroquinolone-resistant Neisseria gonorrhoeae, the amino acid mutations in the fluoroquinolone-resistant determining region (QRDR) of the parC gene are an important factor. The aim of the present study was to develop a rapid detection method of a serine 88 to proline substitution in parC which we previously showed as having significantly higher fluoroquinolone minimal inhibitory concentrations...
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