Article
Fluoroquinolone resistance among Neisseria gonorrhoeae isolates from Shanghai, China: detection of quinolone resistance-determining region mutations.
The Indian journal of medical research - 1 Jun 2009
Tiejun Zhang, Xiaoming Zhou, Jilun Zhang, Yinghu Zhang, Yanhua Ren, Yue Chen, Weiming Gu, Tao Zhang, Qingwu Jiang
Abstract excerpt
BACKGROUND & OBJECTIVE: Fluoroquinolone has a broad spectrum of antimicrobial activity, and is widely used for gonorrhoea treatment. However, its efficacy can be compromised by the drug-resistance property of Neisseria gonorrhoeae isolates. Most resistant cases of N. gonorrhoeae are associated with mutations in the quinolone-resistance-determining-region (QRDR) within genes of gyrA and parC. This study was...
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