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Article

Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Mar 2022

Hamasuna Ryoichi, Hanzawa Hiroyuki, Moritomo Ayako, Matsumoto Masahiro, Aono Hisami, Tomisaki Ikko, Akasaka Takaaki, Fujimoto Naohiro, Jensen Jørgen Skov

Abstract excerpt

INTRODUCTION: The mechanisms of fluoroquinolone-resistance of Mycoplasma genitalium were analysed by a new method. METHODS: M. genitalium strains from urinary sediments of patients with urethritis were isolated and examined antimicrobial susceptibilities and the mutations in ParC, GyrA and 23S rRNA. Docking models between gyrase and topoisomerase IV with sitafloxacin showed that two binding modes in which the...

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Identifiers

PMID: 34836778
DOI: 10.1016/j.jiac.2021.11.011

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