Article
Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan.
Sexually transmitted diseases - 1 Mar 2004
Shigemura Katsumi, Shirakawa Toshiro, Okada Hiroshi, Hinata Nobuyuki, Acharya Bishnu, Kinoshita Shohiro, Kofuku Tomomi, Kawabata Masato, Kamidono Sadao, Arakawa Soichi, Gotoh Akinobu
Abstract excerpt
BACKGROUND AND OBJECTIVES: Fluoroquinolone resistance in Neisseria gonorrhoeae has been associated with alternations in the quinolone-resistance determining regions in the gyrA and parC genes. GOAL: The goal of this study was to investigate the correlation between fluoroquinolone minimum inhibitory concentrations (MICs) and mutations in the gyrA and parC genes of 91 N. gonorrhoeae clinical isolates from Japan....
Topics
- Anti-Infective Agents
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Gatifloxacin
- Gonorrhea
- Humans
- Japan
- Levofloxacin
- Male
- Microbial Sensitivity Tests