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Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex

6 Aug 2012

Abstract excerpt

BACKGROUND: Fragile X syndrome is caused by lack of fragile X mental retardation protein (FMRP) due to silencing of the FMR1 gene. The metabotropic glutamate receptors (mGluRs) in the central nervous system contribute to higher brain functions including learning/memory, mental disorders and persistent pain. The transcription factor cyclic AMP-responsive element binding protein (CREB) is involved in important...

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PMID: 22867433
DOI: 10.1186/1756-6606-5-27

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