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Article

Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy

10 Oct 2012

Abstract excerpt

Epilepsy is a disorder of recurrent seizures that affects 1% of the population. To understand why some areas of cerebral cortex produce seizures and others do not, we identified differentially expressed genes in human epileptic neocortex compared with nearby regions that did not produce seizures. The transcriptome that emerged strongly implicates MAPK signaling and CREB-dependent transcription, with 74% of...

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PMID: 23055509
DOI: 10.1523/jneurosci.3408-12.2012

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