Article
CREB selectively controls learning-induced structural remodeling of neurons.
Learning & memory (Cold Spring Harbor, N.Y.) - 18 Jul 2012
Middei Silvia, Spalloni Alida, Longone Patrizia, Pittenger Christopher, O'Mara Shane M, Marie Hélène, Ammassari-Teule Martine
Abstract excerpt
The modulation of synaptic strength associated with learning is post-synaptically regulated by changes in density and shape of dendritic spines. The transcription factor CREB (cAMP response element binding protein) is required for memory formation and in vitro dendritic spine rearrangements, but its role in learning-induced remodeling of neurons remains elusive. Using transgenic mice conditionally expressing a...
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