Article
Evolution of transmitted HIV-1 with drug-resistance mutations in the absence of therapy: effects on CD4+ T-cell count and HIV-1 RNA load.
Antiviral therapy - 1 Jan 2006
Bezemer Daniela, de Ronde Anthony, Prins Maria, Porter Kholoud, Gifford Robert, Pillay Deenan, Masquelier Bernard, Fleury Hervé, Dabis Francois, Back Nicole, Jurriaans Suzanne, van der Hoek Lia
Abstract excerpt
Sequence analysis of HIV-1 from 440 therapy-naive individuals included within the CASCADE study, who seroconverted within 18 months of the last negative test, identified 65 persons infected with a strain carrying resistance-associated mutations. Population-based sequencing was performed for 20 of these individuals during the therapy-free follow-up period. The median time of follow-up was 15 months (interquartile...
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