Article
Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients.
The Journal of antimicrobial chemotherapy - 1 Jun 2013
Hofstra L Marije, Nijhuis Monique, Pingen Marieke, Mudrikova Tania, Riezebos-Brilman Annelies, Simoons-Smit Alberdina M, Van Ham Petra M, Bierman Wouter F W, Wensing Annemarie M J
Abstract excerpt
BACKGROUND: Transmitted resistant HIV may revert to wild-type in the absence of drug pressure due to reduced replication capacity (RC). We observed eight therapy-naive patients infected with HIV harbouring four mutations at nucleoside reverse transcriptase inhibitor (NRTI) resistance-related positions: M41L, T69S, L210E and T215S. If partial reverted resistance patterns like these are detected at baseline,...
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