Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection with the frequently transmitted HIV-1 M41L variant has no influence on selection of tenofovir resistance.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Pingen Marieke, Nijhuis Monique, Mudrikova Tania, van Laarhoven Arjan, Langebeek Nienke, Richter Clemens, Boucher Charles A B, Wensing Annemarie M J

Abstract excerpt

OBJECTIVES: In ∼10% of newly diagnosed HIV-1 patients, drug-resistant viral variants are detected. In such transmitted HIV-1 variants, the thymidine analogue mutation (TAM) M41L is frequently observed as a single resistance mutation and these viral variants often belong to phylogenetic transmission clusters. The presence of at least three TAMs, in particular patterns with M41L/L210W, impairs the efficacy of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Lymphocyte Count

Share to Deoxycytidine

Share to Emtricitabine

Share to HIV Reverse Transcriptase

Share to Organophosphonates

Share to Tenofovir

Source

Identifiers

PMID: 25261422
DOI: 10.1093/jac/dku377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection with the frequently transmitted HIV-1 M41L variant has no influence on selection of tenofovir resistance.PMID 25261422Read ↗

HIV-1 transmission cluster with M41L 'singleton' mutation and decreased transmission of resistance in newly diagnosed Swedish homosexual men.Semantic proximity Read ↗

Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients.Semantic proximity Read ↗

Evolution of transmitted HIV-1 with drug-resistance mutations in the absence of therapy: effects on CD4+ T-cell count and HIV-1 RNA load.Semantic proximity Read ↗

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.Semantic proximity Read ↗

Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir.Semantic proximity Read ↗

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.Semantic proximity Read ↗

Thymidine analogue mutation profiles: factors associated with acquiring specific profiles and their impact on the virological response to therapy.Semantic proximity Read ↗

In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.Semantic proximity Read ↗

Evolution of tenofovir-resistant HIV-1 isolates exposed to tenofovir alafenamide dose escalation.Semantic proximity Read ↗

Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.Semantic proximity Read ↗

Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021).Semantic proximity Read ↗

Impact of a treatment including tenofovir plus didanosine on the selection of the 65R mutation in highly drug-experienced HIV-infected patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.