Genetic variability of glutathione S-transferase enzymes in human populations: functional inter-ethnic differences in detoxification systems.

doi:10.1016/j.gene.2012.09.113

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Article

Genetic variability of glutathione S-transferase enzymes in human populations: functional inter-ethnic differences in detoxification systems.

Gene - 1 Jan 2013

Polimanti Renato, Carboni Cinzia, Baesso Ilenia, Piacentini Sara, Iorio Andrea, De Stefano Gian Franco, Fuciarelli Maria

Abstract excerpt

Glutathione S-Transferase enzymes (GSTs) constitute the principal Phase II superfamily which plays a key role in cellular detoxification and in other biological processes. Studies of GSTs have revealed that genetic polymorphisms are present in these enzymes and that some of these are Loss-of-Function (LoF) variants, which affect enzymatic functions and are related to different aspects of human health. The aim of...

Topics

Alleles
Ethnicity
Gene Frequency
Genetic Variation
Genetics, Population
Genotype
Glutathione Transferase
Humans

Source

Open in PubMed

Identifiers

PMID: 23043933
DOI: 10.1016/j.gene.2012.09.113

Genes

GSTA1
GSTM1
GSTO1
GSTO2
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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